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E targets, depot effect, high encapsulation and transport [38] efficiency, targeted deliveryE targets, depot effect, high encapsulation and transport [38] efficiency, targeted delivery . Polymeric nanoparticles (NPs) consist of polymeric colloidal nanoparticles prepared from biodegradable and biocompatible, natural or synthetic polymers, ranging in sizes from 10 nm to 1 m. A wide variety of

Of compounds. Most of nanocarriers are biodegradable, biocompatible for different routesOf compounds. Most of nanocarriers are biodegradable, biocompatible for different routes of administration (parenteral and non-parenteral administrations), exhibits low toxicity and stability, and they are able to induce strong humoral and cellular [35-37] immune responses without anti-vector immunity . N

Tion virosomes and virosomal adjuvanted formulations are currently applied in commercialTion virosomes and virosomal adjuvanted formulations are currently applied in commercial vaccines (Hepatitis A vaccines: Epaxal and Epaxal junior; Influenza vaccines: Inflexal V and FluAd). Moreover several promising virosome vaccine candidates , (Malaria, HCV breast cancer HIV Candida vaccines) are , , ,

Gp: Glycoprotein; Ab: Antibody; NAbs: Neutralizing antibodies.protein (EGFP) displayed onGp: Glycoprotein; Ab: Antibody; NAbs: Neutralizing antibodies.protein (EGFP) displayed on the E2 surface folded into its active form. We and others have successfully expressed and refolded several HIV-1 antigens and [19,65-67] protein domains . In addition, peptides 1-11 and 2-6 of beta-amyloid were disp

Tion virosomes and virosomal adjuvanted formulations are currently applied in commercialTion virosomes and virosomal adjuvanted formulations are currently applied in commercial vaccines (Hepatitis A vaccines: Epaxal and Epaxal junior; Influenza vaccines: Inflexal V and FluAd). Moreover several promising virosome vaccine candidates , (Malaria, HCV breast cancer HIV Candida vaccines) are , , ,

STEMThe E2 protein scaffold represents a versatile antigen delivery system (ESTEMThe E2 protein scaffold represents a versatile antigen delivery system (E2DISP) where antigenic determinants can be exposed on the surface of an icosahedral [61,62] dodecahedral nanoparticle . The scaffold is composed of the E2 acetyltransferase protein derived from the pyruvate dehydrogenase (PDH) multienzyme c


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