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Zation as delivery systems for medicines and cosmetics as well.1,2 SuchZation as delivery systems for medicines and cosmetics as well.1,2 Such natural surfactants are synthesized in the liver from cholesterol that is used as a precursor for primary BSs, mainly chenodeoxycholic acid (CDCA) and cholic acid. During fasting, bile is concentrated in the gall bladder, whereas upon food intake, bil

Pecific transport systems, the combination of bile acids and drugs canPecific transport systems, the combination of bile acids and drugs can lead to liver-specific pharmaceuticals.1,3 In the pharmaceutical field, BSs have been exploited to improve hydrophilicity of water-insoluble active pharmaceutical ingredients (such as amphotericin B, resveratrol, and oxaprozin) mainly by the wetting eff

Ve Pharmaceutical Ingredient), Zhang et al50 investigated the effect of BSsVe Pharmaceutical Ingredient), Zhang et al50 investigated the effect of BSs on the intestinal absorption of lipid nanocarriers. Their results showed that BSs could improve Candesartan cellular uptake in Caco-2 cell monolayers via the active processes and the lymphatic targeting mechanism.50 The aforementioned examples

Aceutical field, a direct relationship between endogenous bile and bioavailability ofAceutical field, a direct relationship between endogenous bile and bioavailability of poorly soluble drugs can be elucidated. PL S MM formed after oral administration usually stand behind enhanced solubilization and absorption of poorly soluble drugs.44 In this quest, Figure 2 demonstrates absorption and dig


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